A bottle of Spravato (esketamine) nasal spray is placed on a counter. The setting is clean and clinical, emphasizing the importance of proper medication storage and accessibility.

What Is Spravato®?

A New Option for Treatment-Resistant Depression

If you’ve tried multiple antidepressants without relief, it’s easy to feel discouraged. But there are advanced treatments that may offer new hope. Spravato® (esketamine) is an FDA-approved nasal spray designed for adults with treatment-resistant depression. It works differently than traditional antidepressants and is available by prescription in certified healthcare settings like Turnwell Mental Health.

How Spravato Works

Spravato contains esketamine, a form of ketamine that targets glutamate, a key neurotransmitter involved in mood regulation. Unlike standard antidepressants that often take weeks to work, Spravato may begin to show results more quickly for some individuals.

Spravato is:

  • Administered in-office under medical supervision

  • Combined with an oral antidepressant for best results

  • Designed to support people who haven’t responded to other treatments

It’s not a take-home medication. Each session includes a period of monitored recovery time to ensure your safety and comfort.

Who Might Benefit from Spravato?

Spravato is specifically approved for:

  • Adults with treatment-resistant depression

  • Adults with major depressive disorder and suicidal thoughts or behaviors, as part of a broader treatment plan

It may be a good option if:

  • You’ve tried two or more antidepressants without success

  • You experience intense depressive episodes that don’t improve with talk therapy alone

  • You’re seeking a supervised medical treatment with promising clinical results

Not everyone is a candidate for Spravato. At Turnwell, we provide thorough evaluations to determine if it’s the right fit for your unique needs.

What to Expect From Treatment

During each session, you’ll self-administer the nasal spray in a quiet, comfortable clinical setting. A trained provider will monitor your vitals and mental state during the observation period, which usually lasts about two hours.

Most patients begin with twice-weekly treatments, which may taper based on progress and provider guidance.

Some people report feeling more emotionally stable, less overwhelmed, or more hopeful after a few sessions. Like all treatments, results vary, and Spravato works best as part of a comprehensive care plan.

Explore Your Options With Turnwell

You don’t have to keep living under the weight of depression that doesn’t respond to standard care. If you’re wondering whether Spravato is right for you, Turnwell Mental Health is here to guide you through every step.

Become a patient to schedule a consultation and learn more about Spravato and other innovative treatments for depression.

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